Plasma exudation and asthma

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REVIEW e of increased airway microvascular permeability and plasma exudation in asthma

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Plasma exudation in the airways: mechanisms and function.

Inflammatory challenges of tracheobronchial and nasal mucosa produce prompt extravasation or exudation of plasma from the well developed microcirculation just beneath the epithelial base. Plasma exudation is not an exaggeration of the normal capilliary exchange of fluid and solutes but a specific inflammatory response of post-capilliary venules. The exuded plasma may not produce oedema. By a ra...

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vin-induced plasma exudation in guinea-pig airways in vivo and the effect of neutrophil depletion

.. n.ofrlhut·lon or neutrophlls to the action or endotoxin on in the airways or anaesthetized guinea-pigs was -•••cu•·•n~ the extra"Yasatlon or E"Yans blue dye. Endotoxin •llhrrflfdtsJ caused a dose-dependent Increase ln mlcro"Yascular blue dye which was maximal arter 2S mln (p<O.OS). The Correspondence: Or T.W. Evans, Dept of Thoracic Medicine, National Heart and Lung Institute, Dovehouse Stre...

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Comparative nasal effects of bradykinin and histamine: influence on nasal airways resistance and plasma protein exudation.

BACKGROUND Bradykinin may contribute to the pathogenesis of allergic rhinitis. Like histamine, nasal challenge with bradykinin induces rhinorrhoea, nasal blockage, and plasma protein leakage. Their comparative nasal potencies have not, however, been fully elucidated. METHODS Three double blind, randomised, placebo controlled and cross-over studies were undertaken to compare objectively the na...

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Effects and interactions of opioids on plasma exudation induced by cigarette smoke in guinea pig bronchi.

The effects of opioids on cigarette smoke-induced plasma exudation were investigated in vivo in the main bronchi of anesthetized guinea pigs, with Evans blue dye as a plasma marker. Acute inhalation of cigarette smoke increased plasma exudation by 216% above air control values. Morphine, 0.1-10 mg/kg but not 30 mg/kg, inhibited the exudation but had no significant effect on substance P-induced ...

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ژورنال

عنوان ژورنال: Lung

سال: 1988

ISSN: 0341-2040,1432-1750

DOI: 10.1007/bf02714025